diff --git a/src/node_ffi.cc b/src/node_ffi.cc
index 7581da4e7c6e..fe110eeae8ea 100644
--- a/src/node_ffi.cc
+++ b/src/node_ffi.cc
@@ -5,6 +5,7 @@
 #include <cstring>
 #include <limits>
 #include <memory>
+#include <optional>
 #include "base_object-inl.h"
 #include "env-inl.h"
 #include "ffi/data.h"
@@ -13,6 +14,7 @@
 #include "ffi/types.h"
 #include "node_binding.h"
 #include "node_errors.h"
+#include "node_internals.h"
 
 namespace node {
 
@@ -772,6 +774,17 @@ void DynamicLibrary::InvokeCallback(ffi_cif* cif,
     callback_args[i] = ToJSArgument(isolate, cb->args[i], args[i]);
   }
 
+  // When native code invokes the callback from the event loop (for example
+  // through a libuv handle), no callback scope is active. Open one so that
+  // nextTick and microtasks queued by the callback are drained when it
+  // returns, as for Node.js's own callbacks. Callbacks invoked synchronously
+  // during a call into native code already run inside the caller's scope.
+  Context::Scope context_scope(context);
+  std::optional<InternalCallbackScope> callback_scope;
+  if (env->async_callback_scope_depth() == 0) {
+    callback_scope.emplace(env, Object::New(isolate), async_context{0, 0});
+  }
+
   TryCatch try_catch(isolate);
   Local<Function> callback = Local<Function>::New(isolate, cb->fn);
   MaybeLocal<Value> result = callback->Call(
diff --git a/test/ffi/test-ffi-callbacks.js b/test/ffi/test-ffi-callbacks.js
index e402343bbc29..2dca67d6605c 100644
--- a/test/ffi/test-ffi-callbacks.js
+++ b/test/ffi/test-ffi-callbacks.js
@@ -82,3 +82,63 @@ test('ffi callback ref and unref APIs work', () => {
     lib.close();
   }
 });
+
+test('ffi callbacks drain nextTick and microtasks only from the event loop', {
+  skip: common.isWindows,
+}, async () => {
+  const { lib, functions: symbols } = getLibrary();
+  let ran = false;
+  const syncCallback = lib.registerCallback(
+    { arguments: ['i32'], return: 'i32' },
+    (value) => {
+      queueMicrotask(() => { ran = true; });
+      return value;
+    },
+  );
+
+  // The process exports libuv, so a uv timer can invoke the callback from
+  // the event loop with no JS on the stack.
+  const { lib: uvLib, functions: uv } = ffi.dlopen(null, {
+    uv_handle_size: { arguments: ['i32'], return: 'u64' },
+    uv_timer_init: { arguments: ['pointer', 'pointer'], return: 'i32' },
+    uv_timer_start: { arguments: ['pointer', 'pointer', 'u64', 'u64'], return: 'i32' },
+    uv_close: { arguments: ['pointer', 'pointer'], return: 'void' },
+  });
+  const UV_TIMER = 13;
+  const timerSize = Number(uv.uv_handle_size(UV_TIMER)) + 64;
+  const timers = [new Uint8Array(timerSize), new Uint8Array(timerSize)];
+  const { promise, resolve } = Promise.withResolvers();
+  const order = [];
+  const timerCallbacks = [
+    uvLib.registerCallback({ arguments: ['pointer'], return: 'void' }, () => {
+      order.push('callback');
+      process.nextTick(() => order.push('nextTick'));
+      queueMicrotask(() => order.push('microtask'));
+    }),
+    // The second timer runs right after the first one, with no Node.js
+    // callback in between that could drain the queues instead.
+    uvLib.registerCallback({ arguments: ['pointer'], return: 'void' }, () => {
+      resolve([...order]);
+      for (const timer of timers) uv.uv_close(timer, 0n);
+    }),
+  ];
+
+  try {
+    // A callback invoked synchronously runs inside the caller's scope, so its
+    // microtasks must not run before the native call returns.
+    assert.strictEqual(symbols.call_int_callback(syncCallback, 1), 1);
+    assert.strictEqual(ran, false);
+
+    const loop = ffi.getCurrentEventLoop();
+    for (let i = 0; i < timers.length; i++) {
+      assert.strictEqual(uv.uv_timer_init(loop, timers[i]), 0);
+      assert.strictEqual(uv.uv_timer_start(timers[i], timerCallbacks[i], 0n, 0n), 0);
+    }
+    assert.deepStrictEqual(await promise, ['callback', 'nextTick', 'microtask']);
+    // Let the uv_close() of the timer handles complete.
+    await new Promise(setImmediate);
+  } finally {
+    lib.close();
+    uvLib.close();
+  }
+});