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@WayScience

The Way Lab

The Way Lab at CU Anschutz

Welcome to the open-source GitHub organization hosted by The Way Lab.

We are a team of scientists and engineers developing methods and software for analyzing microscopy images of cells. Our mission is to reduce human suffering.

Our website contains complete details of our research projects, team members, and funding: https://www.waysciencelab.com/

Check out a few of our open-source projects!

Select Software

Select Projects

We are leading multidisciplinary scientists in a variety of team-science initiatives.

Pediatric Cancer Cell Morphology Atlas

We are developing a reference Cell Painting data set of pediatric cancer cell lines, and performing several high-throughput, high-content phenotypic drug screens.

3D profiling of Neurofibromatosis Type 1 patient-derived organoids

We are developing a 3D image analysis pipeline to profile patient-derived organoids from neurofibromatosis type 1 (NF1) patients, and we will be performing several high-throughput, high-content phenotypic drug screens.

Finding new therapeutics for cardiac fibrosis

We are identifying fundamental differences between cardiac fibroblasts from patients with and without heart failure, and we are developing a high-throughput, high-content phenotypic drug screen to identify new therapeutics for cardiac fibrosis.

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  1. pccma pccma Public

    Pediatric Cancer Cell Morphology Atlas

    Jupyter Notebook 2

  2. ZedProfiler ZedProfiler Public

    Featurizing high-content 3D microscopy images

    Python 2 3

  3. buscar buscar Public

    Single cell hit calling for high-content screens

    Python 9 4

  4. ome-arrow ome-arrow Public

    Using OME specifications with Apache Arrow for fast, queryable, and language agnostic bioimage data.

    Python 8 1

  5. iceberg-bioimage iceberg-bioimage Public

    A format-agnostic framework for cataloging and querying bioimaging data (Parquet, OME-Zarr, OME-TIFF) with Apache Iceberg

    Python 3 2

  6. nf1_schwann_cell_painting_data nf1_schwann_cell_painting_data Public

    This repository contains all the modules to perform image-based analysis with CellProfiler on NF1 Schwann cell data.

    Jupyter Notebook 8 6

Repositories

Showing 10 of 110 repositories
  • buscar Public

    Single cell hit calling for high-content screens

    WayScience/buscar's past year of commit activity
    Python 9 BSD-3-Clause 4 8 1 Updated Oct 30, 2026
  • RxRx19a-reanalysis Public

    Single-cell phenotypic reversal in RxRx19a

    WayScience/RxRx19a-reanalysis's past year of commit activity
    Jupyter Notebook 0 BSD-3-Clause 3 4 1 Updated Oct 29, 2026
  • pccma Public

    Pediatric Cancer Cell Morphology Atlas

    WayScience/pccma's past year of commit activity
    Jupyter Notebook 0 BSD-3-Clause 2 4 1 Updated Oct 29, 2026
  • WayScience/NF1_3D_organoid_profiling_pipeline's past year of commit activity
    Jupyter Notebook 4 BSD-3-Clause 4 16 3 Updated Oct 29, 2026
  • ome-arrow Public

    Using OME specifications with Apache Arrow for fast, queryable, and language agnostic bioimage data.

    WayScience/ome-arrow's past year of commit activity
    Python 8 BSD-3-Clause 1 7 0 Updated Oct 28, 2026
  • predicting_mouse_cardiac_fibrosis Public

    This repository contains image analysis, image-based profiling, and machine learning pipelines to predict cardiac fibrosis signature from mouse fibroblasts. [Name subject to change]

    WayScience/predicting_mouse_cardiac_fibrosis's past year of commit activity
    0 BSD-3-Clause 1 0 0 Updated Oct 28, 2026
  • formascute Public

    🐢 Exploring the structure of software workflow execution through small, reproducible experiments.

    WayScience/formascute's past year of commit activity
    MiniZinc 0 BSD-3-Clause 1 0 1 Updated Oct 27, 2026
  • nf1_schwann_cell_morphology_signature Public

    This repository contains all the modules to split and train a binary classification model to predict NF1 null and wildtype genotype.

    WayScience/nf1_schwann_cell_morphology_signature's past year of commit activity
    Jupyter Notebook 0 BSD-3-Clause 3 0 0 Updated Oct 23, 2026
  • NF1_organoid_profile_analysis Public

    This repo contains analysis code of profiles generated in multiple image-based profiling repos.

    WayScience/NF1_organoid_profile_analysis's past year of commit activity
    Jupyter Notebook 1 BSD-3-Clause 3 5 16 Updated Oct 21, 2026
  • WayScience/beyond2D-review's past year of commit activity
    0 BSD-3-Clause 1 0 2 Updated Oct 20, 2026